"The ACAS was also a very fast automated program like MiToBo but was much more consistent in distinguishing the cells from the open area. In directly comparing the SketchAndCalc with the ACAS analysis, the WT cells had a 25% closure for the ACAS and a 26% closure for the SketchAndCalc and for the knocked-out cell line it was reported to have a 15% closure by the ACAS system and 13% by the SketchAndCalc program. These results support that the efficient analysis by the ACAS software provides reliable analysis of cell migration assay data."
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Multiple clinical and preclinical studies (AML, liver cirrhosis, myelodysplastic syndrome, CML) used Automated Cellular Analysis System (ACAS, MetaVi-Harmony software) to quantify neutrophil and T cell migration.
Applications: prognosis prediction, patient outcome monitoring, drug response evaluation, and mechanistic insights into immune function.
Used in FastTrack AI for nanoparticle research (ACS Nanoscience Au) to automatically track cell motility when tuning nanoparticle coatings.
Benefits: Automated tracking minimized bias, standardized quantification intervals, and allowed high-throughput comparisons.
In Ravnic's micropuncture and hydrogel scaffold series (Small, Microcirculation, Angiogenesis, PRS Global Open, Journal of Controlled Release), MetaVi Labs' AI-powered vascular image analysis was applied.
Tasks: quantifying vessel density, branch/loop counts, total tube length, and vessel diameter. Validated as a bias-free, automated method to assess engineered vascular networks in tissue scaffolds.
Used in studies of RHOA mutations in T-cell lymphoma, Treg suppression of CD8+ motility, and matrix remodeling.
Impact: The software enabled consistent, quantitative motility measurements across diverse immune cell types.
Academic posters (e.g., University of San Diego wound healing assay) highlight its adoption for wound healing and scratch assays, demonstrating efficient, reproducible analysis compared to manual or semi-automated tools.
Studies citing MetaVi Labs' tools appear in Nature Materials, Liver International, Journal of Leukocyte Biology, BMC Cancer, JCI Insight, ACS Nanoscience Au, Small, Angiogenesis, PRS Global Open, Journal of Controlled Release, Cancers (MDPI).
Significance: This breadth proves global scientific trust and multi-disciplinary relevance (immunology, oncology, biomaterials, tissue engineering, nanomedicine).
MetaVi Labs software powers breakthrough discoveries across immunology, oncology, regenerative medicine, and nanotechnology. Our AI-driven image analysis platforms — FastTrack AI and the Automated Cellular Analysis System (ACAS, MetaVi-Harmony) — deliver unbiased, quantitative insights that leading researchers trust to publish in the world's top journals.
Cited in Nature Materials, Liver International, Journal of Leukocyte Biology, Small, Angiogenesis, and more.
Automated analysis removes human bias, ensures reproducibility, and accelerates discovery.
From scratch assays to engineered vascular networks, MetaVi Labs software adapts to your workflow.
Chosen by global leaders in academia, clinical research, and biotech.
For example, fully characterize immune cell to pathogenic cell interactions.
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