MetaVi Labs has automated the assay that was first used to measure the effect of inhibitory substances on migrating tumor cells.
|Time-lapse Movies of Propranolol (beta-blocker) Treated Breast Cancer Cells|
These are time-lapse movies of untreated and Propranolol treated cells. You can observe the dramatic difference in cell migration over an 10-hour period. The video below are un-treated mda-mb-231 cells over 10 hours in a 3D Collagen matrix. The video is Propranolol treated mda-mb-231 cells over 10 hours in a 3D Collagen matrix. Have a … Continue reading
Beta-blocker use has been shown to reduce metastasis formation and extend life in seven cancer types: colon, mammary, melanoma, ovarian, prostate, non-small cell lung, hepatocellular.
Earlier use of beta-blockers increases efficacy, but improvement in lifespan can be seen at nearly every stage of cancer when used in combination with conventional treatment.
Patients at heightened risk of cancer and patients in remission could be optimal candidates for beta-blocker use as a cancer prophylactic.
Any clinically given dosage seems to be effective, whereas unselective beta-blockers (e.g. propranolol) are more effective than cardioselective beta-blockers (e.g. atenolol). Propranolol use drops the five-year cumulative probability of breast cancer-specific mortality from 26.8% to 9.4% .
More than 90% of cancer deaths are caused by metastasis formation rather than the primary tumor . Active migration of tumor cells is an essential prerequisite for invasion and metastasis formation. Norepinephrine is the most potent activator of cell migration as evidenced in colonic [2,20], mammary , and prostate  cancer cells. This increase is mediated predominantly by beta-2 adrenergic receptors and can therefore be inhibited by clinically established non-selective beta-blockers such as propranolol. The in vivo relevance of these experimental results was confirmed by mice xenograft models using prostate  and breast cancer . Most strikingly, retrospective analyses of data from patients with several types of cancer showed that beta-blockers significantly reduce metastasis formation and consequently prolong the survival time of these patients. Results were obtained in epidemiological studies on breast cancer [7-10], melanoma [11-13], ovarian cancer , prostate cancer [15, 16], non-small cell lung cancer , and hepatocellular cancer  patients. Furthermore, a meta-analysis of these studies provided evidence that the use of beta-blockers can be associated with the prolonged survival of cancer patients, especially in patients with early-stage cancer treated primarily with surgery .
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17. Wang HM, Liao ZX, Komaki R, Welsh JW, O'Reilly MS, Chang JY, Zhuang Y, Levy LB, Lu C, Gomez DR. Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy. Ann Oncol 2013; 24: 1312-1319.
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20. Jansen, L.; Hoffmeister, M.; Arndt, V.; Chang-Claude, J.; Brenner, H. Stage-specific associations between beta-blocker use and prognosis after colorectal cancer. Cancer 2014, 120, 1178–1186.